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New research 887: Cortical hyperexcitability in ECH

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#1 Fri, 19/12/2014 - 12:14
PeterM
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Joined: 21/03/2012 - 15:17

New research 887: Cortical hyperexcitability in ECH

J Pain. 2014 Oct 31. pii: S1526-5900(14)00993-6. doi: 10.1016/j.jpain.2014.10.006. [Epub ahead of print]

Transcranial magnetic stimulation reveals cortical hyperexcitability in episodic cluster headache.

Cosentino G1, Brighina F2, Brancato S1, Valentino F1, Indovino S1, Fierro B1.

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Abstract

Evidence has been provided of involvement of the cerebral cortex in the pathophysiology of cluster headache (CH). Here we investigated cortical excitability in episodic CH patients by using transcranial magnetic stimulation (TMS). In 25 patients with episodic CH and 13 healthy subjects we evaluated the motor cortical response to single-pulse (i.e. motor threshold, MT; input-output curves, I-O curves; cortical silent period, CSP) and paired-pulse TMS (i.e. intracortical facilitation, ICF; intracortical inhibition, SICI) in both hemispheres. Thirteen patients were evaluated outside bout, while the remaining 12 patients were inside bout. Our results showed increased slope of the I-O curves after stimulation of both hemispheres in patients outside bout, and in the hemisphere contralateral to the headache side in patients inside bout. Increased ICF was observed in the hemisphere ipsilateral to the headache side in patients evaluated both outside and inside bout; reduced SICI was observed in patients inside bout ipsilaterally to the side of pain. In conclusion, we provide evidence of increased cortical excitability in episodic CH both outside and inside bout, especially in the hemisphere ipsilateral to the side of headache attacks. Our results suggest that an abnormal regulation of cortical excitability could be involved in the pathophysiology of CH.

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We investigated cortical excitability in episodic cluster headache by using transcranial magnetic stimulation, providing evidence of cortical hyperexcitability in patients both inside and outside bout. We suggest that an abnormal state of cortical excitability could be involved in the pathophysiology of the disease.

ATB
P.

Fri, 19/12/2014 - 13:05
Phil
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Last seen: 3 years 11 months ago
Joined: 26/02/2014 - 17:02

Have we a clue what cortical hyper-excitability symptoms are?
Could it explain, for example, a weird sense of humour?

_________________________________________________________________________ Yeah I know, my coat's already on.

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