OUCH(UK) Organisation for the Understanding of Cluster Headache

Donate

Advice Line

01646 651 979

overseas +44 1646 651 979

New research 827: Recent pathophysiology of CH

1 post / 0 new
#1 Tue, 03/12/2013 - 15:36
PeterM
PeterM's picture
Offline
Last seen: 2 years 2 months ago
Joined: 21/03/2012 - 15:17

New research 827: Recent pathophysiology of CH

[quote]Rinsho Shinkeigaku. 2013;53(11):1125-7.

 

[b]The recent pathophysiology of cluster headache (trigeminal autonomic cephalalgias; TACs).[/b]

 

Shimazu T.

Source

Neurology, Saitama Neuropsychiatric Institute.

 

Abstract

 

Background

Cluster headache (CH), known as one of the trigeminal autonomic cephalalgias, is a stereotyped primary pain syndrome characterized by unilateral severe pain, the pathophysiology of which are not well understood.

 

Pathophysiology

The underlying pathophysiology of CH is incompletely understood. The periodicity of the attacks suggests the involvement of a biologic clock within the hypothalamus which controls circadian rhythms, with central disinhibition of the nociceptive and autonomic pathways, the trigeminal nociceptive pathways. Positron emission tomography and voxel-based morphometry have identified the posterior hypothalamic gray matter as the key area for the basic defect in CH. Functional hypothalamic dysfunction has been confirmed by abnormal metabolism based on the N-acetylaspartate neuronal marker in magnetic resonance spectroscopy. A recent case study demonstrated the release of both trigeminal and parasympathetic neuropeptides during a bout of pain in the same pattern previously described in CH. It is hypothesis that trigeminal activation leads to reflex autonomic activation. At a clinical level, there should be a pain threshold above which autonomic symptoms occur, modified by the highly somato- topic and functionally organized central connections of the trigeminovascular system. [/quote]

ATB
P.

Login to add comments

Share This

© OUCH(uk) 2020 | email: info@ouchuk.org
Registered Charity No. 1091919 | Registered in England Company No. 04339368