OUCH(UK) Organisation for the Understanding of Cluster Headache

Donate

Advice Line

01646 651 979

overseas +44 1646 651 979

New research 863: 5-HTTLPR polymorphism in CH not significant

1 post / 0 new
#1 Wed, 24/09/2014 - 14:21
PeterM
PeterM's picture
Offline
Last seen: 2 years 3 months ago
Joined: 21/03/2012 - 15:17

New research 863: 5-HTTLPR polymorphism in CH not significant

J Headache Pain. 2014 Jul 21;15:46. doi: 10.1186/1129-2377-15-46.

Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache.

Schürks M1, Frahnow A, Diener HC, Kurth T, Rosskopf D, Grabe HJ.

Author information

Abstract

BACKGROUND:

Triptans are only effective in terminating cluster headache (CH) attacks in 70-80% of patients. Pharmacogenetic aspects of the serotonin metabolism, specifically variation in the 5-HTTLPR may be involved.

METHODS:

Genetic association study in a well-defined cohort of 148 CH patients with information on drug response to triptans. CH was diagnosed according to the criteria of the International Headache Society. Genotypes of the 43-bp insdel (rs4795541) and A > G (rs25531) polymorphisms in the 5-HTTLPR promoter region were detected by restriction fragment length polymorphism analysis. We used logistic regression analysis to investigate the association between bi-allelic and tri-allelic genotypes and triptan non-response with genotype models.

RESULTS:

Mean age at study entry among patients was 44.6 ± 10.5 years, 77.7% were men. The genotype distribution both for the bi-allelic and the tri-allelic polymorphism was in Hardy-Weinberg equilibrium. We did not find an association of the bi-allelic polymorphism with triptan non-response. While the effect estimates for the S variant of the tri-allelic polymorphisms suggested increased odds of triptan non-response in CH patients (multivariable-adjusted odds ratio [95% confidence interval]: L*L* genotype-reference; L*S* genotype-1.33 [0.53-3.32]; S*S* genotype-1.46 [0.54-3.98]), the results were not statistically significant.

CONCLUSIONS:

Data from our study do not indicate a role of bi-allelic and tri-allelic genotypes of the 5-HTTLPR polymorphism in triptan non-response in CH.

ATB
P.

Login to add comments

Share This

© OUCH(uk) 2020 | email: info@ouchuk.org
Registered Charity No. 1091919 | Registered in England Company No. 04339368